P08043: Mass Spectrometry Sample Prep
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Establish Target Specifications

Table of Contents

Step 1. Prepare the List of Metrics

The table below presents the metrics, or engineering specifications, that will be used by the team to design against.

List of Metrics
Metric No. Metric Importance Units
1 Drop Rate 9 Hz
2 Temperature 9 Kelvin
3 Humidity 6 Kg of water vapor
4 Diffusion Layer Thickness 9 um
5 Contact Angle 6 Theta
6 Droplet Size 6 um
7 Number of Layers 9 unit
8 Image Resolution of Diffusion Slide 9 NA
9 Size of experimental apparatus 3 NA
10 Assembly 3 NA
11 Manufacturing 3 NA
12 Time 3 seconds
13 Durable 6 NA
14 Robust 6 NA
15 Weight 6 kg

Ranks (1,3,6,9), with 9 being the highest and 1 being the lowest.

The metrics, or engineering specifications, that you created in the preceding list should be directly related to the customer needs. In other words, if you have created an engineering specification, it should have some relationship to a need imposed by the customer or the marketplace. Use the table below to map your customer needs against the metrics (or engineering specifications). In many design and product development circles, the rows along the left is often referred to as the voice of the customer, while the columns across the top are often referred to as the voice of the engineer.

Customer Needs as Related to Engineering Metrics Matrix
Needs and Engineering Metrics Spray Pressure Temperature Humidity Diffusion Layer Thickness Droplet Size Number of Layers Image Resolution of Diffusion Slide Size of experimental apparatus Assembly Manufacturing Time Durable Robust Weight
Ink Jet Printer x X x x x x x x x x x
Blade Coating x X x x x x x x x x x
Airbrush x X x x x x x x x x x
Diffusion Slide x x x x x x x x
Implement Controls System - GUI x x x
Low Cost x x x x x
User Friendly Interface x x x x x x x x x
Repeatable x x x x x

Step 2. Collect Competitive Benchmarking Information

Relatively few Sr. design projects start from a clean sheet of paper. In most cases, there are some baseline solutions or products that could meet the vast majority of the customer's needs.

Write one or two paragraphs about each benchmark solution from the market place. Include a picture of the product, preferably illustrating the product in use or operation.

Benchmark 1
Modify Ink Jet Printer

A low cost ink jet printer will be purchased for this senior design project. The hardware, electrical and mechanical components will be modified to meet the customer needs and objectives. A GUI will control the ink jet printer and a custom diffusion slide for the ink jet printer will be created.

Image:ink jet.jpg

Background-Ink Jet Printer

Background-Controlling an Ink Jet Printer

Benchmark 2
Blade Coating

A blade coating device will be designed and fabricated using RIT's CNC machines. The design will mimic a commercial scale blade coating device. The blade coating device will consist of mechanical, electrical and hardware components. This blade coating device will be controlled using a GUI.

Image:Blade Coat 2.jpg

Background-Blade Coating

Benchmark 3
Airbrush

A low cost airbrush will be purchased for this senior design project. The airbrush should be similar to the medical airbrush. This airbrush will serve as a base-line in the MS thesis device comparison analysis. All operating components of the airbrush will be manual controlled, same as the medical application. A custom diffusion slide for the airbrush will be created.

Image:Airbrush.jpg

Background-Airbrush

Benchmark 4
BRUKER MALDI ImagePrep

Bruker Manufactures MALDI instruments for medical applications. The ImagePrep is a Matrix Deposition Device for MALDI Imaging in Biomarker Discovery, Drug Imaging and Pathology Research.

The new ImagePrep device provides highly reproducible sample preparations for MALDI Imaging in a fully automated, push-button process. At the same time, it enables excellent spectra quality at high image resolution of 50 micron.

Image:ImagePrep.jpg

Bruker ImagePrep Background

Video of how the ImagePrep works

Use this table below to compare how pre-existing solutions should compare against the design team's efforts. See the example Table 5-6 on Page 80 of the text by Ulrich and Eppinger.

Competitive Benchmarking Matrix
Metric No. Need Nos. Metric Importance Units Benchmark 1 Benchmark 2 Value Benchmark 3 Value Benchmark 4 Value
1 Need 1,3 Ink Jet Printer 9 NA Apply organic solvent with an ink jet printer Investigate Bruker's ImagePrep coating technologies and applications
2 Need 1,3 Blade Coating 9 NA Design of new blade coat device Investigate Bruker's ImagePrep coating technologies and applications
3 Need 2 Control System for Ink Jet and Blade Coating 9 NA Customer-user control of ink jet Customer-user control of blade coat Customer-user control of Bruker's ImagePrep
4 Need 4 Interface Issues 6 NA User friendly operational control User friendly operational control User friendly operational control User friendly operational control
5 Need 1,2 Measure Diffusion 9 NA Coat a ink jet diffusion slide Coat a blade coat diffusion slide Coat an airbrush diffusion slide Investigate Bruker's ImagePrep imaging technologies and applications
6 Need 5 Purpose for constructing coating device 9 NA Image quality depends on coating process Image quality depends on coating process Image quality depends on coating process Investigate Bruker's ImagePrep commercial applications

Step 3. Set Ideal and Marginally Acceptable Target Values

Given the customer needs, awareness of the marketplace, and resource limitations of the current project, assign preliminary engineering specifications on each of the metrics. In addition to setting the nominal or target value or each specification, provide guidance to the team on the ideal value or direction that the team should strive for, once the nominal target values have been realized.

List of Metrics
Metric No. Need Nos. Metric Importance Units Marginal value Ideal Value
1 Need 1,3 Ink Jet Printer 9 um Organic solvent thickness of 10-15 um Organic solvent thickness of 12 um
3 Need 1,3 Blade Coating 9 um Organic solvent thickness of 10-15 um Organic solvent thickness of 12 um
2 Need 2 Control System for Ink Jet and Blade Coating 9 List (Binary) Yes, no specific marginal value Yes, no specific ideal value
4 Need 4 Interface Issues 6 NA Yes, no specific marginal value Yes, no specific ideal value
5 Need 1,2 Measure Diffusion 9 Quality/Theta High Resolution of coating process from high speed camera 90 degree contact angles of organic solvent
6 Need 5 Purpose for constructing coating device 9 NA Meet basic customer needs and specifications All customer needs and requirements are met
List of Potential Metrics
Metric No. Metric Importance Units Marginal value Ideal Value
1 Temperature 9 degrees F Ambient TBD
3 Humidity 9 Kg of water vapor TBD TBD
2 Drop Rate (Rate of drops being fired) 6 kHz 40 - 70 kHz 70 kHz
4 Droplet Size 6 pico-liters 4-6 pico-liters 3 pico-liters
5 Contact Angle 6 Theta 45 - 90 degree contact angle 90 degree contact angle
6 Diffusion Thickness 9 um 10-15 micrometers 12 micrometers

Step 4. Reflect on the Results and the Process

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