P08043: Mass Spectrometry Sample Prep
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Project Overview

Matrix Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI) is used to examine organic tissue structures and properties. Tissues are coated with an organic solvent to prepare the tissue sample for MALDI imaging. The methods in which tissues are coated affect the image quality and resolution. The desire for high image quality drives the need for advanced coating devices.

Understanding thin film coating process will lead to improved coating devices, which is critical for high image quality. Designing different coating devices will help better understand the tissue coating dynamics.

This senior design project will provide the basic platform for a MS thesis project.

MALDI
Mouse Embryo Brain Tissue
public/MALDI image of Mouse Embryo - www.burker.com.jpg

public/MALDI image of Mouse Embryo - www.burker.com.jpg

public/MALDI Brain Tissue - University of Vanderbilt.jpg

public/MALDI Brain Tissue - University of Vanderbilt.jpg

public/System Integration.jpg

public/System Integration.jpg

Administrative Information

Project Name
Mass Spectrometry Sample Preparation
Project Number
P08043
Project Family
Bioengineering Fundamentals Family of Projects
Project Manager
Robert Alpern
Track
Assistive Devices and Bioengineering Track
Start Term
2007-2
End Term
2007-3
Faculty Guide
Dr. Steven Day (ME): swdeme@rit.edu
Faculty Consultant
Dr. Steve Weinstein (ME) : sjweme@rit.edu
Faculty Consultant
Dr. Thomas Smith (Chemistry) : twssch@rit.edu
Primary Customer
Dr. Steven Day
Secondary Customer
Dr. Andy High (St. Jude Children's Hospital)
Email: Anthony.High@STJUDE.ORG
Dr. Clive Slaughter (St. Jude Children's Hospital)
Email: Clive.Slaughter@STJUDE.ORG

Team Documents

This outline for the posting of team created documents follows the general product development process presented in the textbook "Product Design and Development" by Ulrich and Eppinger.

Presentations

Mass Spectrometry Info

MALDI Info

Team info

Review Archives of Past Senior Design Projects

Winter Quarter Team Objectives

NEW Chamber Checklist NEW

Planning

Mission Statement

Staffing Requirements

Intellectual Property Considerations

Preliminary Work Breakdown Structure

Team Values and Norms

Grading and Assessment Scheme

Required Resources

Concept Development

Identify Customer Needs

Establish Target Specifications

Generate Product Concepts

Select Product Concept(s)

Test Product Concept(s)

Set Final Specifications

System Level Design

Product Architecture

Detail Design

Design for Manufacturing and Assembly

Robust Design

Design for the Environment and Sustainability

Design for Reliability

Design for Safety

Testing and Refinement

Prototyping

Published Documents

As you conclude the project, include links to all of your finished and fully polished documents here. The previous sections of the web site contain the entire design history of your project. This section contains the finished products. Add more links as needed.

Concept Design Review Documents (SD I)

Detailed Design Review Documents (SD I)

Managerial Design Review Presentation (SD I)

Technical Conference Publication (SD II)

Poster Publication (SD II)

Managerial Design Review Presentation (SD II)

Photo Gallery