P18081: Mechanical Bioreactor
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Systems Design

Table of Contents

Team Vision for System-Level Design Phase

During the Systems Design phase, Team MYSCLE generated general design alternatives for the mechanical bioreactor. The feasibility of these alternatives was evaluated using customer needs and benchmarking. Detailed subsystem design for the best model and testing of components will begin in the next phase.

Functional Decomposition

Figure 1: Device Functional Decomposition

Figure 1: Device Functional Decomposition

Benchmarking

Figure 2: Benchmarking (Developments in a Research Setting)

Figure 2: Benchmarking (Developments in a Research Setting)

Figure 3: Benchmarking (On the Market)

Figure 3: Benchmarking (On the Market)

Feasibility

Figure 4: Budget Feasibility

Figure 4: Budget Feasibility

Figure 5: The CAD Model Assembly for the Hole and Peg System is illustrated above (Note: This model is not complete, it simply shows how we plan to attach the membrane to the actuator and strain the chamber). This assembly consists of two components, an actuating arm and the cell membrane chamber. The actuating arm (dark gray component of the model) will be machined from a metal, which is still to be determined. This square platform consists of a cylindrical arm (which will connect to an actuator) and two pins (which will fasten the membrane to the platform). This actuating arm will move in the x-direction to stretch the membrane uni-axially. The cell membrane chamber (transparent component of the model) will be made of molded polydimethylsiloxane (PDMS) polymer, and channels on either side of the membrane will attach to an actuating arm (pictured above) and a fixed platform (not pictured) respectively to achieve uniaxial strain.

Figure 5: The CAD Model Assembly for the Hole and Peg System is illustrated above (Note: This model is not complete, it simply shows how we plan to attach the membrane to the actuator and strain the chamber). This assembly consists of two components, an actuating arm and the cell membrane chamber. The actuating arm (dark gray component of the model) will be machined from a metal, which is still to be determined. This square platform consists of a cylindrical arm (which will connect to an actuator) and two pins (which will fasten the membrane to the platform). This actuating arm will move in the x-direction to stretch the membrane uni-axially. The cell membrane chamber (transparent component of the model) will be made of molded polydimethylsiloxane (PDMS) polymer, and channels on either side of the membrane will attach to an actuating arm (pictured above) and a fixed platform (not pictured) respectively to achieve uniaxial strain.

Morphological Chart

Figure 6: Morphological Chart (Design Concepts to Mechanically Strain Cells)

Figure 6: Morphological Chart (Design Concepts to Mechanically Strain Cells)

Concept Development (System Alternatives)

Figure 7: Concept Generation Alternative 1 (Clamp System)

Figure 7: Concept Generation Alternative 1 (Clamp System)

Figure 8: Concept Generation Alternative 2 (Roller System)

Figure 8: Concept Generation Alternative 2 (Roller System)

Figure 9: Concept Generation Alternative 3 (Probing System)

Figure 9: Concept Generation Alternative 3 (Probing System)

Figure 10: Concept Generation Alternative 4 (Hole and Peg System)

Figure 10: Concept Generation Alternative 4 (Hole and Peg System)

Concept Development (Pugh Analysis - Selecting "Best" Alternative)

Figure 11: Initial Pugh Analysis ( Datum = Clamp System )

Figure 11: Initial Pugh Analysis ( Datum = Clamp System )

Figure 12: Secondary Pugh Analysis ( Datum = Hole and Peg )

Figure 12: Secondary Pugh Analysis ( Datum = Hole and Peg )

Systems Architecture

Figure 13: Systems Architecture

Figure 13: Systems Architecture

Risk Assessment

Figure 14: Risk Assessment (Systems Level Design Updates)

Figure 14: Risk Assessment (Systems Level Design Updates)

Design Review Materials

TEAM MYSCLE'S Design Review Presentation can be found here

Plans for next phase

TEAM MYSCLE'S Project Plan for Phase III is outlined in the MSDI PIII Gantt Chart. In this phase, we will complete component testing and create detailed subsystem designs.

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